I am really, really shocked right now. I migrated our R&D lab (we are a very small team that develop automated scientific instruments) from Windows XP to Windows 10 last year, solving a lot of issues with well, everything, and using VMs to run old windows XP custom data loggers for instruments (weird custom serial APIs).
However, the forced updates, lock-screens, and unsigned-driver issues (serial port adapters, USBASP programmers, etc.) with Windows 10 have been an absolute nightmare. Its been whack-a-mole with problems due to the changes made on Windows 10 (every other system update requires redefining COM ports), and any attempt to be "future-proof" utilizing Microsoft platforms has proven to be a an exercise in futility.